Melatonin modulates the fetal cardiovascular defense response to acute hypoxia
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چکیده
منابع مشابه
Melatonin modulates the fetal cardiovascular defense response to acute hypoxia
Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction. However, the effects of melatonin on the fetal defense to acute hypoxia, such as that which may occur during labor, remain unknown. This translational study tested the hypothesis, in vivo, tha...
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In complicated pregnancy, fetal hypoxemia rarely occurs in isolation but is often accompanied by fetal acidemia. There is growing clinical concern about the combined effects of fetal hypoxemia and fetal acidemia on neonatal outcome. However, the effects on the fetal defense responses to acute hypoxemia during fetal acidemia are not well understood. This study tested the hypothesis that fetal ac...
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WHAT CONSTITUTES FETAL stress, and what are the implications of fetal stress in the course of fetal development? Thakor and Giussani (17) address a fundamental component of the fetal stress response: acidemia and it role as a modulator of the hypothalamus-pituitary-adrenal (HPA) axis responsiveness to hypoxia. Fetal stress responsiveness has long been studied from the perspective of fetal survi...
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The role of the different mechanisms involved in the cardiovascular response to hypoxia [chemoreceptors, baroreceptors, lung stretch receptors, and central nervous system (CNS) hypoxic response] is analyzed in different physiological conditions by means of a mathematical model. The results reveal the following: 1) The model is able to reproduce the cardiovascular response to hypoxia very well b...
متن کاملAcute cardiovascular response to isocapnic hypoxia. I. A mathematical model.
A mathematical model of the acute cardiovascular response to isocapnic hypoxia is presented. It includes a pulsating heart, the systemic and pulmonary circulation, a separate description of the vascular bed in organs with the higher metabolic need, and the local effect of O(2) on these organs. Moreover, the model also includes the action of several reflex regulatory mechanisms: the peripheral c...
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ژورنال
عنوان ژورنال: Journal of Pineal Research
سال: 2015
ISSN: 0742-3098,1600-079X
DOI: 10.1111/jpi.12242